Generated:Article Title: Key differences between 13 KRAS mutation detection technologies and their relevance for clinical practice
Article Snippet: .. Technology Regulatory status Platform Chemistry Manufacturer Data generated by: therascreen® KRAS RGQ PCR Kit FDA-approved IVD CE-IVD Qiagen Rotorgene Q therascreen® KRAS RGQ PCR Kit Qiagen AstraZeneca, Cambridge, UK cobas® KRAS Mutation Test FDA-approved IVD CE-IVD Roche cobas z480 cobas® KRAS Mutation Test Roche Molecular Systems AstraZeneca, Cambridge, UK IdyllaTM KRAS Mutation Test CE-IVD Biocartis IdyllaTM platform IdyllaTM KRAS Mutation Test Biocartis Biocartis, Mechelen, Belgium iPLEX® Pro Tests Research use only Agena Bioscience MassARRAY® 4 iPLEX® Pro Agena Bioscience NewGene Ltd, Newcastle – Upon-Tyne, UK UltraSEEKTM Research use only Agena Bioscience MassARRAY® 4, ULTRASEEK Agena Bioscience Agena Bioscience, Inc, CA, USA ThunderBoltsTM Cancer Panel Research use only Illumina MiSeq. .. RainDrop Source, MiSeq V3 RainDance Technologies Illumina Bioprocessing Solutions Alliance, IN, USA OncomineTM Focus Assay Research use only Ion Torrent PGM Ampliseq, ThermoFisher Life Technologies Clinical Services Lab, West Sacramento, CA, USA Sentosa® SQ NSCLC Panel CE-IVD Ion Torrent PGM, Thermofisher Sentosa® SQ Vela Diagnostics Vela Diagnostics, Singapore Illumina Nextera® Rapid Capture Custom Lung Panel Research use only Illumina Nextera® V3 Illumina Birmingham Women’s Hospital NHS, West Midlands Regional Genetics Laboratory, UK Ion AmpliSeqTM Cancer Hotspot Panel v2 Research use only Ion Torrent PGM Ion Ampliseq Cancer Hotspot Panel v2 ThermoFisher Addenbrookes, East Anglia NHS Clinical Genetics Laboratory, Cambridge, UK TruSight® Tumor 15 Research use only Illumina OGP panel V3 chemistry Illumina Illumina, CA, USA PrimePCR ddPCR Mutation Assays KRAS Research use only BioRAD Bio-Rad QX200 Prime PCR KRAS mutation assays BioRad IMGM Laboratories, Germany Sanger capillary sequencing Research use only 3730 capillary sequencer Big Dye 1.1 Applied Biosystems IMGM Laboratories, Germany SUPPLEMENTARY METHODS 1 therascreen® and cobas® KRAS mutation testing was performed at AstraZeneca 2 laboratories, while all other KRAS mutation testing methods and assays were performed at 3 10 external partner laboratories where KRAS testing is conducted routinely to assist clinical 4 practice, or conducted for research purposes.
Polymerase Chain Reaction:Article Title: Key differences between 13 KRAS mutation detection technologies and their relevance for clinical practice
Article Snippet: .. Technology Regulatory status Platform Chemistry Manufacturer Data generated by: therascreen® KRAS RGQ PCR Kit FDA-approved IVD CE-IVD Qiagen Rotorgene Q therascreen® KRAS RGQ PCR Kit Qiagen AstraZeneca, Cambridge, UK cobas® KRAS Mutation Test FDA-approved IVD CE-IVD Roche cobas z480 cobas® KRAS Mutation Test Roche Molecular Systems AstraZeneca, Cambridge, UK IdyllaTM KRAS Mutation Test CE-IVD Biocartis IdyllaTM platform IdyllaTM KRAS Mutation Test Biocartis Biocartis, Mechelen, Belgium iPLEX® Pro Tests Research use only Agena Bioscience MassARRAY® 4 iPLEX® Pro Agena Bioscience NewGene Ltd, Newcastle – Upon-Tyne, UK UltraSEEKTM Research use only Agena Bioscience MassARRAY® 4, ULTRASEEK Agena Bioscience Agena Bioscience, Inc, CA, USA ThunderBoltsTM Cancer Panel Research use only Illumina MiSeq. .. RainDrop Source, MiSeq V3 RainDance Technologies Illumina Bioprocessing Solutions Alliance, IN, USA OncomineTM Focus Assay Research use only Ion Torrent PGM Ampliseq, ThermoFisher Life Technologies Clinical Services Lab, West Sacramento, CA, USA Sentosa® SQ NSCLC Panel CE-IVD Ion Torrent PGM, Thermofisher Sentosa® SQ Vela Diagnostics Vela Diagnostics, Singapore Illumina Nextera® Rapid Capture Custom Lung Panel Research use only Illumina Nextera® V3 Illumina Birmingham Women’s Hospital NHS, West Midlands Regional Genetics Laboratory, UK Ion AmpliSeqTM Cancer Hotspot Panel v2 Research use only Ion Torrent PGM Ion Ampliseq Cancer Hotspot Panel v2 ThermoFisher Addenbrookes, East Anglia NHS Clinical Genetics Laboratory, Cambridge, UK TruSight® Tumor 15 Research use only Illumina OGP panel V3 chemistry Illumina Illumina, CA, USA PrimePCR ddPCR Mutation Assays KRAS Research use only BioRAD Bio-Rad QX200 Prime PCR KRAS mutation assays BioRad IMGM Laboratories, Germany Sanger capillary sequencing Research use only 3730 capillary sequencer Big Dye 1.1 Applied Biosystems IMGM Laboratories, Germany SUPPLEMENTARY METHODS 1 therascreen® and cobas® KRAS mutation testing was performed at AstraZeneca 2 laboratories, while all other KRAS mutation testing methods and assays were performed at 3 10 external partner laboratories where KRAS testing is conducted routinely to assist clinical 4 practice, or conducted for research purposes.
Mutagenesis:Article Title: Key differences between 13 KRAS mutation detection technologies and their relevance for clinical practice
Article Snippet: .. Technology Regulatory status Platform Chemistry Manufacturer Data generated by: therascreen® KRAS RGQ PCR Kit FDA-approved IVD CE-IVD Qiagen Rotorgene Q therascreen® KRAS RGQ PCR Kit Qiagen AstraZeneca, Cambridge, UK cobas® KRAS Mutation Test FDA-approved IVD CE-IVD Roche cobas z480 cobas® KRAS Mutation Test Roche Molecular Systems AstraZeneca, Cambridge, UK IdyllaTM KRAS Mutation Test CE-IVD Biocartis IdyllaTM platform IdyllaTM KRAS Mutation Test Biocartis Biocartis, Mechelen, Belgium iPLEX® Pro Tests Research use only Agena Bioscience MassARRAY® 4 iPLEX® Pro Agena Bioscience NewGene Ltd, Newcastle – Upon-Tyne, UK UltraSEEKTM Research use only Agena Bioscience MassARRAY® 4, ULTRASEEK Agena Bioscience Agena Bioscience, Inc, CA, USA ThunderBoltsTM Cancer Panel Research use only Illumina MiSeq. .. RainDrop Source, MiSeq V3 RainDance Technologies Illumina Bioprocessing Solutions Alliance, IN, USA OncomineTM Focus Assay Research use only Ion Torrent PGM Ampliseq, ThermoFisher Life Technologies Clinical Services Lab, West Sacramento, CA, USA Sentosa® SQ NSCLC Panel CE-IVD Ion Torrent PGM, Thermofisher Sentosa® SQ Vela Diagnostics Vela Diagnostics, Singapore Illumina Nextera® Rapid Capture Custom Lung Panel Research use only Illumina Nextera® V3 Illumina Birmingham Women’s Hospital NHS, West Midlands Regional Genetics Laboratory, UK Ion AmpliSeqTM Cancer Hotspot Panel v2 Research use only Ion Torrent PGM Ion Ampliseq Cancer Hotspot Panel v2 ThermoFisher Addenbrookes, East Anglia NHS Clinical Genetics Laboratory, Cambridge, UK TruSight® Tumor 15 Research use only Illumina OGP panel V3 chemistry Illumina Illumina, CA, USA PrimePCR ddPCR Mutation Assays KRAS Research use only BioRAD Bio-Rad QX200 Prime PCR KRAS mutation assays BioRad IMGM Laboratories, Germany Sanger capillary sequencing Research use only 3730 capillary sequencer Big Dye 1.1 Applied Biosystems IMGM Laboratories, Germany SUPPLEMENTARY METHODS 1 therascreen® and cobas® KRAS mutation testing was performed at AstraZeneca 2 laboratories, while all other KRAS mutation testing methods and assays were performed at 3 10 external partner laboratories where KRAS testing is conducted routinely to assist clinical 4 practice, or conducted for research purposes.
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